By Dr. Adam Killpartrick
What is Methylation?
We can think of the addition and subtraction of methyl groups as a switch. When a methyl group is added to a compound, a reaction begins. Perhaps it is the turning “on” of a gene or the activation of one enzyme. When a methyl group is taken away from a compound, a reaction such as this is being turned “off.”
Prevalence of Variation Within Methylation Pathways
It has been estimated that 40 percent of the population may have some sort of variation in the MTHFR gene, which regulates the methylenetetrahydrofolate reductase (MTHFR) enzyme and its activity.1 because these variations can directly affect methylation processes through their impact on the folate cycle, they are a necessary component of any conversation about healthy methylation reactions.